APL1β28 trifluoroacetate paʻakai/1233876-42-0 /GT Peptide/Peptide Mea hoʻolako

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He biomarker koʻikoʻi koʻikoʻi no ka hana ʻana o Aβ1-42 i loaa mai kaβAPP-like protein APLP1.Hana ʻia kēia peptide e ka mīkini proteolytic like me Aβ42. Nonamyloid APL1β28 hiki ke ʻike ʻia ma CSF, a pili kona pae me Aβ42 hana.ʻO kona lakio i ka huina APL1β (APL1β25, APL1β27, a me APL1β28) ua hoʻonui nui ʻia i nā hihia AD ʻohana a sporadic.ʻIke ʻia e like me ka pauka keʻokeʻo, ua hoʻohui ʻia ka peptide a hoʻohana wale ʻia no ka noiʻi ʻepekema, ʻaʻole no ka hoʻohana kanaka.Aia nā kūlana mālama mai ka 80 maikaʻi ʻole° C i ka 20 maikaʻi ʻole° C.

Nā kikoʻī

ʻAno: Keʻokeʻo a keʻokeʻo pauka

Maʻemaʻe (HPLC):≥98.0%

Hoʻokahi haumia:≤2.0%

Maʻiʻo Acetate (HPLC): 5.0%～12.0%

Waiwai (Karl Fischer):≤10.0%

Maʻiʻo Peptide:≥80.0%

Hoʻopili a me ka hoʻouna ʻana: Haʻahaʻa haʻahaʻa, hoʻopaʻa haʻahaʻa, pololei i ka mg e like me ka makemake.

Pehea e kauoha ai?

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2. E kauoha ma ka pūnaewele.E ʻoluʻolu e hoʻopiha i ka palapala kauoha ma ka pūnaewele.

3. Hāʻawi i ka inoa peptide, CAS No. a i ʻole ke kaʻina, ka maʻemaʻe a me ka hoʻololi inā makemake ʻia, ka nui, a me nā mea ʻē aʻe e hāʻawi mākou i kahi ʻōlelo i loko o 2 mau hola.

4. E kauoha i ka conformation e ka aelike kuai i kakau pono ia a me ka NDA (non disclosure agreement) a i 'ole ka aelike huna.

5. E hoʻomau mau mākou i ka holomua o ke kauoha i ka manawa.

6. Hāʻawi ʻia ka peptide e DHL, Fedex a i ʻole nā ​​​​mea ʻē aʻe, a me HPLC, MS, COA me ka ukana.

7. E hahai ʻia ke kulekele hoʻihoʻi inā he ʻokoʻa o kā mākou maikaʻi a lawelawe paha.

8. ʻO ka lawelawe ma hope o ke kūʻai aku: Inā he nīnau kā mākou mea kūʻai e pili ana i kā mākou peptide i ka wā o ka hoʻokolohua, e ʻoluʻolu e kelepona iā mākou a e pane mākou iā ia i ka manawa pōkole.

Hoʻohana wale ʻia nā huahana a pau o ka hui no ka noiʻi ʻepekema, ʻo ia's pāpā ʻia e hoʻohana pololei ʻia e kekahi kanaka ma ke kino kanaka.

FAQ：

ʻO wai ka hopena maikaʻi loa no kaʻu noiʻi?

Ma ka maʻamau, hoʻopau ka peptide me kahi hui amino manuahi N-terminal a me kahi hui carboxyl manuahi C-terminal.Hōʻike pinepine ka peptide sequence i ke kaʻina o ka protein makuahine.I mea e pili kokoke ai i ka protein makuahine, pono e pani pinepine ka hopena o ka peptide, ʻo ia hoʻi, n-terminal acetylation a me C-terminal amidation.Ke pale nei kēia hoʻololi i ka hoʻokomo ʻana i ka uku keu, a ʻoi aku ka hiki ke pale i ka hana exonucliase, i ʻoi aku ka paʻa o ka peptide.

ʻO wai nā polypeptides i hoʻololi ʻia i hiki ke synthesized i ka peptide Kina?

Hāʻawi kā mākou hui i nā ʻano lepili peptide i hoʻololi ʻia, e like me ka acetylation, biotin labeling, phosphorylation modification, fluorescence modification, hiki ke hana ʻia e like me kāu mau pono kūikawā.

Pehea ʻoe e hoʻopau ai i nā polypeptides?

ʻO ka solubility o ka polypeptide e hilinaʻi nui ʻia i kona ʻano kumu mua a me ke kula kiʻekiʻe, ke ʻano o ka lepili hoʻololi, ke ʻano solvent a me ka ʻike hope.Inā hiki ʻole ke hoʻoheheʻe ʻia ka peptide i ka wai, hiki i ke ultrasound ke kōkua i ka hoʻopau ʻana.No ka peptide kumu, ua ʻōlelo ʻia e hoʻoheheʻe me 10% acetic acid;No nā peptides acidic, hoʻopau ʻia me 10%NH4HCO3.Hiki ke hoʻohui ʻia nā solvents organik i nā polypeptides insoluble.Hoʻoheheʻe ʻia ka peptide i ka liʻiliʻi liʻiliʻi o ka solvent organik (eg, DMSO, DMF, isopropyl alcohol, methanol, etc.).Manaʻo nui ʻia e hoʻoheheʻe ʻia ka peptide i loko o ka mea hoʻoheheʻe organik ma mua a laila hoʻohui mālie ʻia i ka wai a i ʻole ka mea pale ʻē aʻe a hiki i ka manaʻo i makemake ʻia.

He aha nā kūlana mālama maikaʻi loa?Pehea ka paʻa o ka peptide?

Ma hope o ka lyophilized, hiki i ka polypeptide ke hana i ka fluff a i ʻole flocculant pauka, hiki ke pale i ka hōʻino mua ʻana o ka polypeptide.Manaʻo ʻia no ka mālama ʻana: a.-20℃mālama a maloʻo paha b.E ho'āʻo e hōʻalo i ka hoʻoheheʻe hou ʻana c.E ho'āʻo e pale i ka waiho ʻana ma ke kūlana hoʻonā (hiki ke mālama ʻia ka pauda maloʻo maloʻo i loko o nā pūʻolo kaʻawale no ka maʻalahi o ka hoʻohana ʻana) d.Inā pono e mālama ʻia i loko o ka hopena, ʻōlelo ʻia e hoʻopau i nā peptides i ka wai sterile ma lalo o nā kūlana acidic nāwaliwali a mālama i ka -20℃.

Pehea ka lawe ʻia ʻana o kaʻu peptide?He aha nā hōʻike hoʻāʻo i hāʻawi ʻia?

Hoʻopaʻa mau ʻia nā polypeptides maloʻo maloʻo a pau i loko o nā pahu kūikawā o 2 ml a i ʻole 10ml me ka ʻikepili analytical kumu a me nā hōʻike synthesis i loaʻa nā ʻike koʻikoʻi e like me ke kaʻina, ke kaumaha molekala, ka maʻemaʻe, ke kaumaha, a me ka helu o ka polypeptide.

He aha ke kaumaha ʻupena?He aha ka peptide content?

Ma hope o ka lyophilized peptide e like me ka fluffy a me ka fluff-like, hiki ke loaʻa ka nui o ka wai, adsorbed solvents a me nā paʻakai ma muli o nā ʻano o ka peptide ponoʻī.ʻAʻole kēia manaʻo ʻaʻole lawa ka maʻemaʻe o ka peptide, akā ua hoʻemi ʻia ka ʻike maoli o ka peptide e 10% a 30%.ʻO ke kaumaha nui o ka peptide ke kaumaha maoli o ka peptide me ka wai a me nā ion protonated.I mea e hōʻoia ai i ka neʻe ʻana o ka peptide, pono e wehe ʻia nā mea non-peptide mai ka peptide crude.

Pehea ka maʻemaʻe o ka peptide?

Hiki i kā mākou hui ke hāʻawi i nā pae hoʻomaʻemaʻe like ʻole no nā mea kūʻai aku e koho mai, mai ka crude a i> 99.9% maʻemaʻe.Wahi a nā mea kūʻai aku hiki iā mākou ke hāʻawi i ka maʻemaʻe> 99.9% ultra-pure polypeptide.