Peptide KuʻunaHoʻohuihuilawelawe
ʻO Hangzhou Go Top Peptide Biotech , i hoʻokumu 'ia i ka makahiki 2014, he a National High-tech Enterprisekūikawā i ka noiʻi, hoʻomohala a me ka hana ʻana i nā peptides a me nā derivatives pili.
ʻO ka huikikowaena noiʻi peptideaia i kēia manawa ma Qiantang Districtof Hangzhou, e uhi ana i kahi o 3,000 square meters.ʻO kahui's hale hana aia ma No.24, Haitian Road, Shangyu District, Shaoxing city, Zhejiang province.Aia kekahi ʻelua mea kanu hui, hookahi noʻoihana peptide GMP hana aia maKalana ʻo Anji o ka ʻāina ʻo Zhejiang, ho'okahi no API mole li'ili'i aia maʻO ke kūlanakauhale ʻo Yuncheng o ka ʻāina ʻo Shanxi.Lilo mākouhe ʻoihana ʻenehana kiʻekiʻe, hoʻohui i ka noiʻi, pilot scale-up, commercialization a me nā kūʻai honua.
Aia ka huipau100limahana,a ua loaʻahoʻomohala ʻoi aku ma mua o40 lāʻau lapaʻau makuapeptides,ma mua o10 mea hoʻopaneʻeua ʻae ʻia.Ua ʻōlelo ʻo Thiki iā ia ke hana i kēlā me kēia makahikiis a i100 kilokani, ka helu o nā peptides maʻamau i loaʻa ua hiki aku ma luna o 20,000.Hiki iā mākou ke hāʻawi i nā lawelawe peptide hoʻokahi mai ka noiʻi (mg) i ka hoʻolaha (KGs).
Papa Hoʻololi Peptide
N-hoʻololi terminal
| {N-Me-Ala} | {N-Me-Asp} | {N-Me-Glu} | {N-Me-Ile} |
| {N-Me-Leu} | {N-Me-Met} | {N-Me-Nle} | {N-Me-Nva} |
| {N-Me-Phe} | {N-Me-Ser} | {N-Me-Thr} | {N-Me-Tyr} |
| {N-Me-Val} | {Sar} | N-Me-Arg | N-Me-Asn |
| N-Me-beta-Ala | N-Me-Gln | N-Me-Lys | N-Me-Trp |
C-hoʻololi terminal
| {Mono Disulfide bridge} | {Palua Disulfide bridge} | {Uhaka ʻekolu Disulfide} |
| {Uhaka Disulfide Random} | {Same Seq.Alahaka Inter-Disulfide } | {Ke alahaka Inter-Disulfide like ʻole} |
| {Amide cyclic (hope)} | {Amide cyclic (ʻaoʻao kaulahao)} | {A i ʻole kaulahao ʻaoʻao Amide cyclic} |
| {Maikaʻi ʻo Thioester cyclic} | {ka pōkā lactone} | {Sec cyclic} |
Nā ʻakika amino ʻokoʻa
| {2-Aze} | {3-Aze} | {5,5-Dime-Pro} |
| {5-ASA} | {Abu} | {Ac-Lys} |
| {Aib} | {Beta-Asp} | {Bpa} |
| {Cha} | {Chg} | {Cit} |
| {Cpg} | {Cys(Acm)} | {Cys(Bzl)} |
ʻO nā peptides i kapa ʻia ʻo Isotope
| Lys(13C6,15N2) | Ile(13C6,15N) |
| Leu(13C6,15N) | Val(13C5, 15N) |
| Arg(13C6, 15N4) |
ʻO nā hoʻololi peptide fluorescent / pālua FRET
| Biotin- | Dansyl- | Hoʻopiʻi ʻia ka peptide fluocent |
| Biotin-Ahx- | Dansyl-Ahx- | ʻO Dabcyl |
| 5-FAM- | Cy3- | Dabcyl / Glu(Edans)-NH2 |
| 5-FAM-Ahx- | Cy5- | Dansyl- |
| FITC- | MCA/DNP | Dansyl-Ahx- |
| FITC-Ahx- | AMC | Edans / Dabcyl |
Huihui Peptide
| BSA(-COOH o ka pahu C | KLH(-NH2 o N pahu hopu) | OVA(-COOH o ka pahu C) |
| BSA Conjugation ma Cys | KLH Conjugation on Cys | OVA(-NH2 o ka pahu N) |
| Hoʻohui ʻia ʻo OVA ma Cys |
Phosphorylation
| {pSer} | {D-pSer} |
| {pTyr} | {D-pTyr} |
| {pThr} | {D-pThr} |
Nā hoʻololi ʻē aʻe (PEGylation, Cyclic modifications, Disulfide Bridges)
| PEGylation | Hoʻololi cyclic | Nā Alahaka Disulfide |
| {Mini-PEG1} | Poʻo i ka huelo cyclic | {Mono Disulfide bridge} |
| {Miki-PEG2} | {Palua Disulfide bridge} | |
| {PEG-11} | {Uhaka ʻekolu Disulfide} | |
| {PEG-12} | {Uhaka Disulfide Random} | |
| …… | …… | …… |