ʻO Penicillin ka lāʻau antibiotic mua loa o ka honua i hoʻohana ʻia i ka hana lapaʻau.Ma hope o nā makahiki o ka hoʻomohala ʻana, ua ulu aʻe ka nui o nā lāʻau antibiotic, akā ʻo ka pilikia o ke kūʻē ʻana i ka lāʻau i hoʻokumu ʻia e ka hoʻohana nui ʻana o nā lāʻau antibiotic ua lilo i mea koʻikoʻi.
Manaʻo ʻia nā peptides antimicrobial he ākea noi no ka nui o kā lākou hana antibacterial kiʻekiʻe, ākea ākea antibacterial spectrum, ʻano like ʻole, ka laulā koho ākea, a me nā ʻano hoʻololi haʻahaʻa haʻahaʻa i nā ʻano kuʻuna.I kēia manawa, nui nā peptides antimicrobial i ka pae noiʻi lapaʻau, ma waena o nā magainins (Xenopus laevis antimicrobial peptide) i komo i ka Ⅲ hoʻokolohua lapaʻau.
Nā mīkini hana i wehewehe maikaʻi ʻia
ʻO nā peptides antimicrobial (amps) nā polypeptides maʻamau me ke kaumaha molekala o 20000 a he hana antibacterial.Ma waena o ~ 7000 a i haku ʻia he 20 a 60 mau koena amino acid.Loaʻa ka hapa nui o kēia mau peptides ikaika i ke kumu ikaika, kūpaʻa wela, a me ka antibacterial ākea ākea.
Ma muli o kā lākou hoʻolālā, hiki ke hoʻokaʻawale ʻia nā peptides antimicrobial i ʻehā mau ʻāpana: helical, sheet, extended, a me ke apo.ʻO kekahi mau peptide antimicrobial he hoʻokahi helix a i ʻole pepa, aʻo nā mea ʻē aʻe he ʻano paʻakikī.
ʻO ka hana maʻamau o ka hana o nā peptides antimicrobial he hana pololei lākou i nā membrane cell bacterial.I ka pōkole, hoʻopau nā peptides antimicrobial i ka hiki o nā membrane bacteria, hoʻololi i ka membrane permeability, leak metabolites, a hopena i ka make bacteria.ʻO ke ʻano i hoʻopiʻi ʻia o nā peptides antimicrobial e kōkua i ka hoʻomaikaʻi ʻana i ko lākou hiki ke launa pū me nā membrane cell bacteria.Loaʻa ka hapa nui o nā peptides antimicrobial i ka uku maikaʻi a no laila ua kapa ʻia ʻo cationic antimicrobial peptides.ʻO ka pilina electrostatic ma waena o ka cationic antimicrobial peptides a me ka anionic bacterial membranes e hoʻopaʻa i ka paʻa ʻana o nā peptides antimicrobial i nā membrane bacteria.
ʻO ka hiki ʻana mai o ka lāʻau lapaʻau
ʻO ka hiki i nā peptides antimicrobial ke hana ma o nā mīkini he nui a me nā ala like ʻole e hoʻonui i ka hana antimicrobial akā e hōʻemi pū i ka propensity no ke kū'ē.Ke hana nei ma nā ala he nui, hiki ke hoʻemi nui ʻia ka hiki o ka bacteria ke loaʻa i nā mutation he nui i ka manawa like, e hāʻawi ana i nā peptides antimicrobial maikaʻi ke kūpaʻa.Eia kekahi, no ka nui o nā peptides antimicrobial e hana ana i nā pūnaewele membrane cell bacteria, pono e hoʻololi hou ka bacteria i ke ʻano o ka membrane cell e hoʻololi, a lōʻihi ka manawa e hiki mai ai nā loli he nui.He mea maʻamau ia i ka chemotherapy maʻi maʻi e kaupalena i ke kūpaʻa ʻana o ka tumo a me ke kūʻē ʻana i ka lāʻau ma o ka hoʻohana ʻana i nā mīkini he nui a me nā mea ʻokoʻa.
Maikaʻi ka manaʻo lapaʻau
E hoʻomohala i nā lāʻau antimicrobial hou e pale aku i ka pilikia antimicrobial e hiki mai ana.Ke hele nei ka nui o nā peptides antimicrobial i nā hoʻokolohua lapaʻau a hōʻike i ka hiki ke maʻi.Nui nā hana i koe e hana ʻia ma nā peptides antimicrobial e like me nā mea hana antimicrobial hou.ʻAʻole hiki ke lawe ʻia ka nui o nā peptides antimicrobial i nā hoʻokolohua lapaʻau i ka mākeke ma muli o ka maikaʻi ʻole o ka hoʻolālā hoʻokolohua a i ʻole ka pono ʻole.No laila, ʻoi aku ka nui o nā noiʻi e pili ana i ka pilina o nā antimicrobial e pili ana i ka peptide me ke kaiapuni kanaka paʻakikī e loiloi i ka hiki maoli o kēia mau lāʻau.
ʻOiaʻiʻo, nui nā pūhui i loko o nā hoʻokolohua lapaʻau i hoʻololi i nā hoʻololi kemika e hoʻomaikaʻi i kā lākou mau lāʻau lapaʻau.Ma ke kaʻina hana, ʻo ka hoʻohana ikaika ʻana i nā hale waihona puke kikohoʻe kiʻekiʻe a me ka hoʻomohala ʻana i nā polokalamu hoʻohālike e ʻoi aku ka maikaʻi o ka noiʻi a me ka hoʻomohala ʻana i kēia mau lāʻau lapaʻau.
ʻOiai he hana koʻikoʻi ka hoʻolālā a me ka hoʻomohala ʻana o nā peptides antimicrobial, pono mākou e hoʻoikaika e kaupalena i ke kūʻē ʻana o nā mea antimicrobial hou.ʻO ka hoʻomau ʻana o ka hoʻomohala ʻana i nā ʻano antimicrobial a me nā mīkini antimicrobial e kōkua i ka palena o ka hopena o ka pale ʻana i nā antibiotic.Eia kekahi, ke kau ʻia kahi mea antibacterial hou ma ka mākeke, pono ka nānā ʻana a me ka hoʻokele kikoʻī e kaupalena i ka hoʻohana pono ʻole o nā mea antibacterial e like me ka hiki.
Ka manawa hoʻouna: Jul-04-2023