Pelekania: Omiganan
Pelekania: Omiganan
Helu CAS: 204248-78-2
Huina molekala: C₉₀H₁₂₇N₂₇O₁₂
Kaumaha molekula: 1779.15
Kaʻina: ILRWPWWPWRRK-NH2
ʻAno: ka pauka keʻokeʻo keʻokeʻo keʻokeʻo
Pehea e hana ai ʻo Omiganan:
He peptide liʻiliʻi loa ia a no laila paʻakikī ke ʻike a hoʻopaʻa inoa no ka proteolysis;Hoʻopili ʻia ia ma ka C terminus e pale hou aku i ka proteolysis a wehe i ka hoʻopiʻi maikaʻi ʻole o ka hui carboxyl.He amphiphilic a hiki ke launa pū me ka membrane cell.Manaʻo ʻia ʻo membrane cell kekahi o kā lākou pahuhopu nui.He polycation ia e makemake i kā lākou launa pū ʻana me nā membrane bacteria i hoʻopiʻi maikaʻi ʻia a me ka zomeric o waho o ka lipopolysaccharide (LPS) me nā membrane mammalian ma mua o ka peptidoglycan.I loko o ka maʻi bacteria, ʻoi aku ka maikaʻi ʻole o ka membrane ma mua o nā pūnaewele mammalian, hiki ke hoʻonui i ka paʻa ʻana a me ka unuhi ʻana.ʻO kahi kumu hope loa ka maʻi maʻi i loaʻa i ka antiinflammatory cytidine ka hana ma nā erythrocytes, ʻoiai ʻo Omiganan e ʻike ʻia he emi hemolytic.E like me ka mea i ʻōlelo ʻia ma luna, aia nā koena i hoʻopiʻi ʻia o ka omiga-nan ma kahi kokoke i kēlā me kēia pahu, ma kahi mamao mai ke kikowaena hydrophobic o ka peptide, a piʻi ka nui o ka uku maikaʻi o ka peptide mai 4+ a i 5+, hiki ke wehewehe ʻia e ka hemolysis emi. , no ka mea, ʻaʻole maikaʻi kēia mau hoʻololi no nā mea like peptide e pili ana me nā membrane mammalian zwitt-rionic.Hoʻopili ʻia kēia e nā hopena o Staubitz a me nā mea ʻē aʻe, kahi e pili ana ka ʻāpana kikowaena o ka cetin antiinflammatory conserved i ka omiganan me ka hana, ʻoiai ʻo ka ʻāpana terminal e hoʻoponopono i ka kikoʻī o ka pahuhopu.
Hoʻohana ʻia ʻo Omiganan no:
ʻO Omiganan kahi moʻolelo synthetic cationic antimicrobial peptide i kēia manawa e hoʻomohala ʻia nei no ka pale ʻana i nā maʻi pili i ka catheter a no ka mālama ʻana i ka haki a me ka rosacea.Ma kēia haʻawina, ua loiloi mākou i ka maikaʻi o ka noi topical o ka omiganan gel i ʻelua mau hiʻohiʻona implant ʻili (i ka ʻili puaʻa vivo a me ka ʻili puaʻa vivo).Ua hoʻāʻo ʻia ʻo omiganan0 i kahi hoʻohālike ex vivo porcine skin colonization model 1 a i ka 2% o ka gel agent i hōʻike i kahi hopena ikaika i hilinaʻi ʻia e kūʻē i ka Gram-positive a me Gram-negative bacteria a me nā mea hū, me nā hopena kiʻekiʻe i ʻike ʻia ma waena o 1 a me 2%.ʻAʻohe ʻokoʻa koʻikoʻi o ka hana ma waena o ka methicillin-resistant and susceptible Staphylococcus aureus, a ʻaʻole i hoʻopilikia ʻia ka hana lāʻau e ka nui o ka mea inoculated.ʻO ka Omiganan1% gel he hana antimicrobial wikiwiki, me ka ho'ēmiʻana o 2.7log (10) i nā pūʻulu colony-forming o Staphylococcus epidermolis / kahua ma 1 h a me ka 5.2log (10) ho'ēmi i ka flagella / kahua ma 24 h ma hope o ka noi.Ua hōʻoia ʻia ka ikaika antibacterial a me ka hana antifungal o Omiganan1% gel e nā haʻawina ʻē aʻe i loko o kahi ʻano hoʻohālikelike ʻili iʻa dolphin.I ka hōʻuluʻulu manaʻo, ua hōʻike ʻia nā gels Omiganem i ka hopena bactericidal a me ka hopena bactericidal me kahi hopena i hilinaʻi nui ʻia ma kahi ākea ākea o nā mea maʻi.Hōʻike hou kēia mau hopena i ka hiki o ka lāʻau lapaʻau ma ke ʻano he lāʻau antimicrobial topical.
Ka manawa hoʻouna: Jun-27-2023