ʻO nā ʻokoʻa i nā kaiapuni kahi i hoʻohana ʻia ai nā paʻakai TFA, acetate, a me ka hydrochloride i ka peptide synthesis

I ka wā o ka peptide synthesis, pono e hoʻohui ʻia kekahi paʻakai.Akā he nui nā ʻano paʻakai, a ʻo nā ʻano paʻakai like ʻole e hana i nā peptides like ʻole, a ʻaʻole like ka hopena.No laila i kēia lā ke koho nui mākou i ke ʻano kūpono o ka paʻakai peptide i ka peptide synthesis.

1. Trifluoroacetate (TFA): He paʻakai kēia i hoʻohana mau ʻia i nā huahana peptide, akā pono e pale ʻia i kekahi mau hoʻokolohua ma muli o ka biotoxicity o trifluoroacetate.Eia kekahi laʻana, nā hoʻokolohua pūnaewele.

2. Acetate (AC): ʻO ka biotoxicity o ka acetic acid he mea liʻiliʻi loa ia ma mua o ka trifluoroacetic acid, no laila ka nui o nā peptides pharmaceutical a me cosmetic e hoʻohana i ka acetate, akā aia kekahi mau huahana i ka acetate paʻa, no laila pono e noʻonoʻo ʻia ka paʻa o ke kaʻina.Ua koho ʻia ʻo Acetate no ka hapa nui o nā hoʻokolohua cell.

3. Hydrochloric acid (HCL): ʻAʻole i koho ʻia kēia paʻakai, a hoʻohana wale kekahi mau kaʻina i ka waika hydrochloric no nā kumu kūikawā.

4. ʻO ka paʻakai Ammonium (NH4 +): E hoʻopilikia nui kēia paʻakai i ka solubility a me ka paʻa o ka huahana, pono e koho ʻia ma ke ʻano.

5. Paʻakai paʻakai (NA+): pili ia i ka paʻa a me ka solubility o ka huahana.

6. Pamoicacid: Hoʻohana pinepine ʻia kēia paʻakai i nā lāʻau peptide e hana i nā mea hoʻokuʻu hoʻomau.

7. CitricAcid: ʻO kēia paʻakai he liʻiliʻi liʻiliʻi o ka physiological toxicity, akā paʻakikī loa kāna hoʻomākaukau ʻana, no laila pono e hoʻomohala ʻia ke kaʻina hana i ka sequentially a kaʻawale.

8. Salicylicacid: Hiki i ka Salicylate ke hoʻopili i ka paʻa o nā huahana peptide, no laila ʻaʻole i hoʻohana pinepine ʻia.

ʻO nā mea i luna nei he mau ʻano paʻakai peptide, a pono mākou e koho e like me nā ʻano o nā paʻakai like ʻole i ka hoʻohana maoli ʻana.