ʻO nā peptides PYY he antifungal a mālama i ke olakino microbial intestinal

I ka ʻike ʻana o ka hui i kēia ʻano o C. albicans me ka hoʻohana ʻana i ka PYY, ua hōʻike ka ʻikepili ua hoʻōki pono ʻo PYY i ka ulu ʻana o kēia mau bacteria, e pepehi ana i nā ʻano fungal o C. albicans a me ka mālama ʻana i ke ʻano hū symbiotic o C. albicans.

Ua paʻi ka hui o Eugene Chang ma ke Kulanui o Chicago i kahi pepa i loko o ka puke moʻolelo Science i kapa ʻia: Peptide YY: A Paneth cell antimicrobial peptide e mālama ana i ka Candida gut commensalism.

ʻO YY peptide (PYY) He hormone ia i hōʻike ʻia a huna ʻia e nā cell enteroendocrine (ECC) e hoʻomalu i ka ʻai ma o ka hoʻoulu ʻana i ka māʻona.Ua ʻike ʻia nā haʻawina hou e hōʻike pū ana ka PanethCell non-specific intestinal i kahi ʻano o PYY, hiki ke hana ma ke ʻano he antimicrobial peptide (AMP), he hana koʻikoʻi hoʻi i ka mālama ʻana i ka microbiota intestinal i ke olakino a pale i ka Candida albicans mai ka lilo ʻana i pathogenic pōʻino. ʻano hana.

ʻAʻole ʻike liʻiliʻi e pili ana i ka hoʻoponopono ʻana o kēia mau bacteria e kā mākou ʻōpū microbiome.ʻIke wale mākou aia ka bacteria ma waho, akā ʻaʻole mākou ʻike i ka mea e maikaʻi ai lākou no ko mākou olakino.Ua hōʻike ʻia nā haʻawina hou he mea nui ka YY peptides no ka mālama ʻana i ka symbiosis bacterial intestinal.

I ka hoʻomaka ʻana, ʻaʻole mākaukau ka hui e aʻo i ka bacteria i loko o ka microbiome ʻōpū.I ka wā e aʻo ana ʻo Joseph Pierre, ka mea kākau mua o ka pepa, i nā cell endocrine intestinal o nā ʻiole e hana ana i ka PYY, ua ʻike ʻo Kauka Joseph Pierre he Panethcells ka PYY, ʻo ia nā mea pale koʻikoʻi i ka ʻōpū mammalian a pale i ka hoʻonui ʻana o nā maʻi bacteria. ma ka metabolizing i kekahi mau pūhui bacterosuppressive.ʻAʻole kūpono kēia no ka mea ua manaʻo mua ʻia ʻo PYY he hormone makemake wale nō.I ka ʻike ʻana o ka hui i nā ʻano bacteria, ua ʻike ʻia ʻo PYY he hewa i ka pepehi ʻana iā lākou.

ʻO nā peptides PYY he antifungal a mālama i ke olakino microbial intestinal

Eia naʻe, i ko lākou ʻimi ʻana i nā ʻano peptides like ʻole, ua loaʻa iā lākou kahi peptide like PYY -Magainin2, kahi peptide antimicrobial i loaʻa ma ka ʻili Xenopus e pale ana i nā maʻi bacterial a me nā fungal.No laila, hoʻomaka ka hui e hoʻāʻo i nā waiwai antifungal o PYY.ʻO kaʻoiaʻiʻo, ʻaʻole wale ʻo PYY he mea hoʻohana antifungal maikaʻi loa akā he ʻano antifungal kikoʻī loa.

Loaʻa iā PYY paʻa, hoʻololi ʻole ʻia he 36 amino acids (PYY1-36) a he peptide antifungal ikaika ke hoʻololi ʻia nā cell Paneth i loko o ka ʻōpū.Akā, i ka wā e hoʻopuka ai nā pūnaewele endocrine i ka PYY, wehe ʻia ʻelua mau amino acids (PYY3-36) a hoʻololi ʻia i hormone ʻōpū e hiki ke hele i loko o ke kahe koko e hana i kahi manaʻo piha e haʻi i ka lolo ʻaʻole ʻoe pōloli.

ʻO Candida albicans (C.albicans), ʻike ʻia hoʻi ʻo Candida albicans, he maʻi bacteria e ulu maʻamau i ka waha, ka ʻili a me ka ʻōpū.He commensal i loko o ke kino ma ke ʻano hū maʻamau, akā ma lalo o nā kūlana haʻahaʻa e hoʻohuli ʻia ia i kahi ʻano fungal i kapa ʻia, hiki iā ia ke ulu nui, e alakaʻi ana i nā maʻi thrups, nā maʻi waha a me ka ʻāʻī, nā maʻi vaginal, a i ʻole ka ʻoi aku ka ʻino. nā maʻi ʻōnaehana.

I ka ʻike ʻana o ka hui i kēia ʻano o C. albicans me ka hoʻohana ʻana i ka PYY, ua hōʻike ka ʻikepili ua hoʻōki pono ʻo PYY i ka ulu ʻana o kēia mau bacteria, e pepehi ana i nā ʻano fungal o C. albicans a me ka mālama ʻana i ke ʻano hū symbiotic o C. albicans.