Hōʻike pōkole kēia pepa i ka ticotide a me kona hopena pharmacological

Tecosactidehe synthetic 24-peptide corticotropin analogue.ʻO ke kaʻina amino acid e like me ka 24 amino acids o ka amino-terminal o ka corticotropin maoli (kanaka, bovine a me ka puaʻa), a loaʻa iā ia ka hana physiological like me ACTH maoli."Hōʻike ʻia ia e ka nele o nā hopena antibody, maʻamau me ka ʻole o nā hopena ʻaoʻao koʻikoʻi, a kūpono loa ia no nā poʻe maʻi i loaʻa i ka maʻi maʻi a ʻaʻole pono i ka porcine corticotropin maoli."

"Hoʻoulu ia i ka hyperplasia adrenal, hoʻoulu i ka huna ʻana o nā hormones adrenocortical, ʻoi aku ka (cortisol) a me kekahi mau mineralocorticoids e like me corticosterone, a hoʻoulu pū i ka huna ʻana o androgens, akā me ka hopena nāwaliwali."

Hōʻike pōkole kēia pepa i ka ticotide a me kona hopena pharmacological

ʻAʻohe hopena liʻiliʻi i ka huna ʻana o aldosterone.ʻO ka hapalua o ke ola he 3 mau hola.I ka makahiki 2008, ua ʻae ka FDA iā Tecokotide mai Novartis no ka hōʻoia ʻana i ka lawa ʻole o ka adrenal.Ke aʻo ʻia nei ia ma RandboudUniversity no ka mālama ʻana i ka nephropathy membranous idiopathic.

ʻO ke ʻano hana hoʻoheheʻe wai holoʻokoʻa ke ʻano synthesis o ticacotide.He nui nā ʻanuʻu o kēia ʻano, ka manawa synthesis lōʻihi, a koi i nā catalysts pipiʻi a me nā mea hana kiʻekiʻe, i loaʻa nā hemahema o ke kumukūʻai kiʻekiʻe, nā haumia he nui, ka pilikia hana, a me nā hua haʻahaʻa.Ua hōʻike ʻia ʻo ka synthesis i kēlā me kēia me ka hoʻohana ʻana i ka hoʻolālā Z-protection, kahi i hoʻohana ʻia ai ka hydrogenation e wehe i ke kahua pale i kēlā me kēia ʻanuʻu, he mau wāwae lōʻihi, hana paʻakikī, kumukūʻai kiʻekiʻe a me nā hua haʻahaʻa.Hoʻopili ʻia ʻo Serine i ka racemization ma muli o ka hui ʻana o hoʻokahi i hoʻokahi i ka wā hoʻomaʻemaʻe, he paʻakikī ke hoʻomaʻemaʻe.

"E like me ka hormone adrenocorticotropic, hoʻoulu ka ticcotide i ka huna ʻana o nā hormones cortical (ʻoi aku ka cortisol) mai ka cortex adrenal."No laila, ʻaʻohe hopena i nā maʻi me ka maʻi adrenocortical koʻikoʻi.

ʻO Ticocotide kahi polypeptide synthetic i loaʻa he 24 amino acids.Ua like kona ano me ka mua a hiki i ka 24th amino acids o ACTH.Hoʻonui wikiwiki ka hoʻokele intravenous i nā pae cortisol koko.Pono e hoʻohana ʻia kahi hoʻoheheʻe intravenous mau e mālama i nā ʻano cortisol koko.No ka hoʻokomo intramuscular, ua hiki i ka serum cortisol kona kiʻekiʻe ma ka hola 1 ma hope o ka hoʻopili ʻana.Ma hope o kēlā, hiki ke mālama ʻia ka cortisol kiʻekiʻe no kahi o 24 mau hola.