ʻO ka L-carnosine kahi mole liʻiliʻi me kahi dipeptide L-ʻano maoli i ʻike maʻamau i ke ʻano a ua haku ʻia me nā ʻano dipeptide L-like maoli i loaʻa ma ke ʻano.He dipeptide i haku ʻia me β-alanine a me L-histidine.Loaʻa iā Carnosine nā ʻano antioxidant cellular, anti-aging and physiological health care functions a me nā hopena olakino, e like me ke hypertension, ka maʻi puʻuwai, senile cataract, ulcer recovery, anti-tumor, immune model test, anti-stress factor a pēlā aku.
Ke kuleana o
ʻO Carnosine kahi carnosine i loaʻa e ka ʻepekema Lūkini ʻo Gulevich me ka carnitine.Ma United Kingdom, Korea, Rūsia, a me nā Kina ʻē aʻe, ua hōʻike ʻia nā haʻawina he mana antioxidant ikaika ka carnosine a he mea pono ia i nā kānaka.Ua hōʻike ʻia ʻo Carnosine e hoʻoneʻe i nā ʻano oxygen reactive (ROS) i hana ʻia e ka nui o ka oxidation o nā momona momona i loko o ka membrane cell i ka wā o ke koʻikoʻi oxidative, a me ka α-β unsaturated aldehydes.
Nui nā haʻawina i ʻike he hopena maikaʻi ka N-acetylcarnosine i ka pale ʻana a me ka mālama ʻana i ka cataract.Ua hōʻike ʻia kekahi o kēia mau haʻawina ua hoʻomaikaʻi ʻia ka carnosine i nā cataracts i hoʻokumu ʻia e nā opacities crystalline i nā ʻiole i hoʻoulu ʻia e ka ʻike ʻana i ka guanidine.ʻOiai ke kākoʻo nei kēia mau ʻōlelo i kekahi mau pōmaikaʻi hypothetical i ka maka e like me ka mālama ʻana i ka carnotin no nā cataracts, ʻaʻole lākou i kākoʻo piha ʻia e ke kaiāulu olakino.No ka laʻana, ua ʻōlelo ka Royal Orthopedics, ʻaʻole palekana a maikaʻi ʻole ka carnosine i ka mālama ʻana i nā maʻi cataracts.
Wahi a kahi hōʻike 2002, hiki i ka carnosine ke hoʻomaikaʻi i ka pilina pili kanaka a hoʻonui i nā huaʻōlelo i hoʻohana ʻia e nā keiki me ka autism, akā hiki mai nā hoʻomaikaʻi i ʻōlelo ʻia ma ke aʻo ʻana mai nā hoʻomaikaʻi, placebo, a i ʻole nā mea ʻē aʻe i kākau ʻole ʻia ma kēia noiʻi.
ʻO ke ʻano o ka synthesis
I kēia manawa, loaʻa i nā ʻano hana o ka carnosine kekahi mau hemahema maʻamau: ma muli o ka palena o ka hopena ʻaoʻao, ua hana ʻia kēia ʻaoʻao me ke komo ʻana o ke apo L-histidine imidazole.E hoʻololi ʻo L-histidine i ka liʻiliʻi o 0.8% i ke kaʻina hana, e hōʻemi ana i ka hua hua;I ka manawa like, he paʻakikī ke hoʻokaʻawale i ka L-carnosine me ka maʻemaʻe optical maʻemaʻe maikaʻi mai nā hui ʻino (kona ʻano rotation, imidazole isomers, a me nā mea ʻē aʻe), e pili ana i ka maʻemaʻe pāʻoihana, no ka mea, ua like kēia mau huila i nā waiwai physicochemical like me L-carnosine.Ma muli o ka loaʻa ʻana o kēia mau hui, ʻo ka L-carnosine ka hopena he mea ʻawaʻawa, ma mua o ka hoʻomākaukau maʻemaʻe mua.
ʻO ke ala hou o ka hana L-carnosine penei: phthalic anhydride reacts β-alanine me phthalic anhydride β-phthaloylalanine, chlorinated reagent chlorides phthaloyl-β-phthaloylalanine i phthaloyl-alanine β-alanyl chloride;L-trialkylsilane mea pale e hoʻopili me ka trialkylchlorosilane a hexahydroxysilane, hana me ka phthalyl β-alanyl chloride condensation o hydrochloride, wehe i ka hui pale me ka waiʻona anhydrous, a synthetates hydrochloride i ka hopena alkaline e loaʻa ai ka huahana synthesis waena, hydralylyzateshydrate hydrazine. L-carnosine i loko o ka waiʻona anhydrous.ʻO kēia huahana he apo imidazole ma L-protected histidine e pale aku i nā hopena ʻaoʻao o ke apo imidazole ma L-histidine a me nā mea ʻē aʻe, a loaʻa iā L-carnosine maʻemaʻe me nā hopena haʻahaʻa haʻahaʻa a me ka huina kiʻekiʻe.
Ka manawa hoʻouna: Oct-24-2023