Mechanism o ka hana protease cysteine

ʻAno hana

ʻO nā enzymes nā pūmua e hoʻolalelale i nā hopena kemika.Hoʻopili ka enzyme me ka substrate e hoʻololi i ka huahana hope.Hoʻopaʻa nā mea pale i kekahi i kekahi no ka pale ʻana i ka substrate mai ke komo ʻana i ka pae hana o ka enzyme a/a i ʻole e pale i ka enzyme mai ka hoʻopololei ʻana i ka hopena.Nui nā ʻano mea paʻa e pili ana: ʻaʻohe kikoʻī, hiki ʻole ke hoʻohuli, hoʻohuli - hoʻokūkū a hoʻokūkū ʻole.Hoʻopili nā mea hoʻopaneʻe hiki ke hoʻohuli ʻia i nā enzyme me nā pilina non-covalent (e laʻa, nā pilina hydrophobic, hydrogen a me nā paʻa ionic).ʻO nā hana hoʻomalu nonspecific e pili ana i ka hoʻopau ʻana i kahi ʻāpana o ka protein o ka enzyme a no laila e pale aku ai i nā hopena kino a i ʻole kemika.Hoʻohana nā mea paʻa paʻa i hoʻokahi enzyme.ʻO ka hapa nui o nā mea ʻawaʻawa e hana e like me nā enzymes mana.ʻO nā mea hoʻopaʻapaʻa hoʻokūkū nā pūhui a pau e like loa me ke ʻano kemika a me ka geometry molekala o ka substrate pane.Hiki i ka mea hoʻopaneʻe ke launa pū me ka enzyme ma ka wahi hana, akā ʻaʻohe hopena.ʻO nā mea hoʻopaneʻe hoʻokūkū ʻole he mau mea ia e launa pū me nā enzymes akā ʻaʻole i pili ka hapa nui ma ka wahi hana.ʻO ke kumu ʻupena o ka mea hoʻokūkū hoʻokūkū ʻole ʻo ia ke hoʻololi i ke ʻano o ka enzyme, a laila e hoʻopilikia ai i ka pūnaewele hana, i hiki ʻole ai i ka substrate ke launa pū me ka enzyme e hana.Hiki ke hoʻohuli ʻia nā mea hoʻopaʻapaʻa non-competitive.Hoʻokumu nā mea hoʻopaneʻe hiki ʻole ke hoʻololi i nā paʻa covalent ikaika me nā enzymes.Hiki i kekahi o kēia mau mea ho'ohilahila ke hana ma luna a puni ka pūnaewele hana.

hoʻohana

Hoʻohana nui ʻia nā enzyme ma nā ʻoihana ʻoihana, e like me ka holoi kīʻaha, nā meaʻai a me nā ʻoihana brewing.Hoʻohana ʻia nā Proteases i nā pauka holoi "microbial" e wikiwiki i ka haki ʻana o nā protein i loko o ka lepo e like me ke koko a me nā hua.ʻO ka hoʻohana pāʻoihana o nā enzymes he mea hiki ke hoʻoheheʻe ʻia i ka wai, he mea paʻakikī ke hana hou ʻana, a ke kāohi nei kekahi mau huahana hopena i ka hana enzyme (mana manaʻo manaʻo).

ʻO nā molekala lāʻau, ʻo ka nui o nā molekala lāʻau he mau mea hoʻopaneʻe enzyme, a ʻike pinepine ʻia nā mea hoʻopiʻi lāʻau lapaʻau e ko lākou kikoʻī a me ka hopena.ʻO ke kiko a me ka hopena kiʻekiʻe i hōʻike ʻia he haʻahaʻa haʻahaʻa nā hopena ʻino a haʻahaʻa haʻahaʻa ka lāʻau.Loaʻa nā mea hoʻopaneʻe enzyme ma ke ʻano a ua hoʻolālā ʻia a hana ʻia ma ke ʻano he ʻāpana liʻiliʻi o ka pharmacology a me ka biochemistry 6.

ʻO nā mea ʻawaʻawa maoli ka hapa nui o nā enzyme inhibitors i ulu e pale i nā lāʻau a i ʻole nā ​​​​holoholona like ʻole mai nā mea ʻaihue.Aia i loko o kēia mau mea ʻawaʻawa ka nui o nā mea ʻawaʻawa loa i ʻike ʻia.


Ka manawa hoʻouna: Apr-25-2023