Nānā a me ka hoʻohana ʻana o cerulein

Nānā nui

ʻO Caerulein, i ʻike ʻia ʻo cerulein, he ʻili ʻili o ka rana Australian HYlacaerulea i loaʻa he 10 amino acids.He mole decapeptide ia i hoʻolako ʻia e ka trifluoroacetate e hana ana ma ke ʻano he cholecystokinin analogue ma nā pancreatic vesicular cell a hiki ke alakaʻi i ka huna ʻana o ka nui o nā enzyme digestive a me ka wai pancreatic, ka hopena o ka edematous pancreatitis acute.Hiki ke hoʻohana ʻia ka Cerutin no ke aʻo ʻana i nā proteins up-regulation Nf-κb e like me ka intercellular adhesion molecule-1 (ICAM-1) i nā mea pili i ka mumū e like me NADPH oxidase a me Janus kinase mediated signal transduction.Ua hoʻohana maikaʻi ʻia e hoʻokumu i nā hiʻohiʻona o ka maʻi pancreatitis ma nā ʻiole, nā ʻiole, nā ʻīlio, a me nā hamsters Syrian (AP).ʻOi aku ka maikaʻi o ka hoʻohana ʻana i nā wai i loko o ke koko e ka intravenous, dermal, a i ʻole intraperitoneal injection.Hoʻohana nui ʻia ia i nā hoʻokolohua lapaʻau o ka edematous pancreatitis acute, a ua hoʻohana ʻia nā hoʻokolohua in vitro i nā hiʻohiʻona cell.Eia kekahi, hoʻohana ʻia no ka nānā ʻana i ka hana gallbladder.

Nānā a me ka hoʻohana ʻana o cerulein

ʻIke kikoʻī

Nānā: ka pauka keʻokeʻo

Helu CAS: 17650-98-5

Helu Gutuo : GT-F055

Kaʻina: pGlu-Gln-Asp-Tyr(SO3H)-Thr-Gly-Trp-Met-Asp-Phe-NH2

Kumu molekala: C58H73N13O21S2

Kaumaha molekula: 1352.4

Solubility: Hoʻoheheʻe ʻia i loko o 50mM ammonium hydroxide ma kahi ʻano o 1.0mg/ml

Palapala noi

1. Hoʻohana nui ʻia ia i ka hoʻohālikelike ʻana o ka maʻi maʻi maʻi pancreatitis i nā hoʻokolohua lapaʻau.

2. No ka hoʻohana ʻana i nā hiʻohiʻona cell in vitro.

3. Hoʻohana ʻia no ka hoʻāʻo ʻana i ka hana gallbladder.

E hoʻomohala i kahi kumu hoʻohālike no ke aʻo ʻana i ka pancreatitis acute no ke aʻo ʻana i ka biology cell cerulein (AP), nā hiʻohiʻona pathophysiological a me nā hōʻike o nā maʻi kūlohelohe i ka maʻi pancreatitis.Ma waho aʻe o ka noiʻi ʻana i nā loli pulmonary o ka maʻi AP, hiki iā ia ke hōʻike maikaʻi i ka pilina endocrine visceral e like me ke kiʻekiʻe o ka metabolin a me CCK.Hiki ke hoʻohana ʻia e loiloi i ka hoʻoponopono hou ʻana a me ka hoʻihoʻi ʻana i nā ʻiʻo ʻeha ma hope o ka pau ʻana o nā mea pōʻino.

5. ʻO ka hoʻohana ʻana i ka Caerulein cerulein (cerulein) a me LPS e hoʻokumu i nā hiʻohiʻona pancreatitis hiki ke hana i nā hopena synergistic, hiki i ka mea mua ke hoʻoulu i nā enzyme pancreatic e luku i ka pancreas, a hoʻomau mau i nā cell inflammatory e hoʻokuʻu i nā mea inflammatory.Ma hope iho, hoʻopau ʻo LPS i ka pane maʻamau o nā mea hoʻolaha inflammatory, no laila ke hoʻomohala nei i ka pancreatitis localized ma ke ʻano he ʻano inflammatory koʻikoʻi.

6. Hiki ke hoʻohana ʻia ʻo Cerulein e pale i ka ʻeha o ka gallbladder, renal colic, a me ka ʻeha claudication intermittent.Manaʻo ʻia ʻo ia he antagonist kephalin endogenous.