Ua ʻike ʻia nā agonists like peptide 1 receptor (GLP-1R) like me Glucagon e hōʻemi i ka hoʻohana ʻana i ka waiʻona i nā rodents a me nā poʻe keu me ka maʻi hoʻohana waiʻona (AUD).Eia nō naʻe, ua hōʻike ʻia nā haʻahaʻa haʻahaʻa o ka semaglutide (semaglutide), kahi mea hoʻopaʻapaʻa ikaika o GLP-1, e hōʻemi i ka hoʻohana ʻana i ka waiʻona i nā rodents a me nā poʻe keu me ka AUD.ʻAʻole ʻike ʻia ka manaʻo o kahi agonist me ka mana kiʻekiʻe a me ka pilina no GLP-1R) i nā pane pili i ka waiʻona i nā rodents, a me nā ʻano neurological lalo.
ʻO Somallutide, kahi lāʻau i hoʻohana ʻia i kēia manawa no ka mālama ʻana i ka maʻi maʻi type 2 a me ka momona, hiki ke lilo i mea lapaʻau maikaʻi no ka hilinaʻi ʻana i ka waiʻona.i loko o kahi noiʻi i paʻi ʻia ma ka puke pai honua eBioMedicine i kapa ʻia "Semaglutide Reduces Alcohol Intake and Relapse-like Drinking in Male and Female Rats," Ua ʻike nā kānaka ʻepekema mai ke Kulanui o Gothenburg a me nā ʻoihana ʻē aʻe e hiki i ka somallutide ke hōʻemi i ka hoʻi hou ʻana o ka waiʻona a me ka inu ʻana i ka waiʻona i nā ʻiole. ʻoi aku ma mua o ka hapalua.
Ua hoʻonui ʻia ka noi no somallutide, i kūʻai ʻia ma lalo o nā inoa inoa e like me Ozempic (semaglutide), mai ka wā i ʻae ʻia ai ka lāʻau lapaʻau no ka mālama ʻana i ka momona, kahi i paʻakikī loa i ka loaʻa ʻana;Ua loaʻa pū kekahi moʻolelo anecdotal o ka poʻe me ka momona a i ʻole ka maʻi diabetes e ʻōlelo ana ua emi ko lākou makemake i ka waiʻona ma hope o ko lākou hoʻomaka ʻana i ka lāʻau.I kēia mau lā, mālama ʻia ka poʻe me ka hilinaʻi waiʻona me ka hui pū ʻana o nā ala psychosocial a me nā lāʻau lapaʻau.ʻEhā mau lāʻau i ʻāpono ʻia i kēia manawa.No ka mea he maʻi ka hilinaʻi ʻana i ka waiʻona me nā kumu he nui a me nā ʻano like ʻole o kēia mau lāʻau lapaʻau, ʻoi aku ka nui o ka hoʻomohala ʻana i nā ʻano lāʻau lapaʻau.
ʻO Somallutide kahi lāʻau lapaʻau lōʻihi e pono ai ka poʻe maʻi e lawe i hoʻokahi manawa i ka pule, a ʻo ia ka lāʻau lapaʻau mua e hana ai i ka mea loaʻa GLP-1 hiki ke lawe ʻia ma ke ʻano he papa.I loko o ke aʻo ʻana, ua mālama ka poʻe noiʻi i nā ʻiole pili i ka waiʻona me ka somalutide, ka mea i hōʻemi nui i ka inu ʻana i ka waiʻona a nā ʻiole i hōʻemi i ka inu ʻana e pili ana i ka hoʻihoʻi ʻana, kahi pilikia nui no ka poʻe me ka hilinaʻi ʻana i ka waiʻona no ka mea e hoʻi hou ka poʻe ma hope o ka wā o ka ʻai ʻana a inu hou i ka waiʻona. mamua o ka lakou hana ole ana.Ua hiki i nāʻiole i mālamaʻia ke hoʻemi i kā lākou inu waiʻona i ka hapalua i ka hoʻohālikelikeʻana i nāʻiole i hanaʻoleʻia, i'ōlelo ai nā mea noiʻi.ʻO kahi ʻike hoihoi i loko o ka haʻawina ʻo ia ka hoʻemi like ʻana o ka somallutide i ka inu ʻana i ka waiʻona i nā ʻiole kāne a me nā wahine.
Ua hōʻike pū ka haʻawina i kahi hopena maikaʻi maikaʻi loa, ʻoiai ʻo nā noiʻi lāʻau lapaʻau o somallutide e lōʻihi loa ana ma mua o ka hiki ke hoʻohana ʻia e mālama i ka hilinaʻi ʻana i ka waiʻona;Ke hele nei i mua, ʻoi aku ka maikaʻi o ka lāʻau lapaʻau no ka poʻe me ke kaumaha nui a me ka hilinaʻi ʻana i ka waiʻona, a ʻōlelo ka poʻe noiʻi hiki ke lawe ʻia nā hopena i nā kānaka, e like me nā haʻawina ʻē aʻe o nā lāʻau lapaʻau hilinaʻi waiʻona e hoʻohana ana i nā hiʻohiʻona noiʻi pili e hōʻike ana e loaʻa paha i nā kānaka nā hopena therapeutic like ʻole. me he iole la.Ua ʻōlelo ʻo Polofesa Elisabet Jerlhag, ʻoiaʻiʻo, aia nā ʻokoʻa ma waena o nā haʻawina i mālama ʻia i nā holoholona a me nā kānaka, a pono e noʻonoʻo nā mea noiʻi i kēia mau ʻokoʻa;I kēia hihia, akā naʻe, ua hōʻike ʻia kahi noiʻi mua i ke kanaka ua ʻike ʻia kahi mana kahiko o kahi lāʻau maʻi diabetes e hana ana ma GLP-1 e hōʻemi i ka inu ʻana i ka waiʻona i nā poʻe keu me ka hilinaʻi ʻana i ka waiʻona.
Ua nānā pū ka haʻawina o kēia manawa i ke kumu e hōʻemi ai ka somallutide lāʻau lapaʻau i ka ʻai ʻana i ka waiʻona pākahi, e hōʻike ana i ka hōʻemi ʻana i ka uku o ka lolo a me nā hoʻopaʻi i mea e hoʻonui ai;I loko o ka pepa, ua ʻike nā mea noiʻi e pili ana i ka uku a me ka ʻōnaehana hoʻopaʻi o ka lolo ʻiole.ʻOi aku ka kikoʻī, pili ia i ka nucleus accumbens area, kahi ʻāpana o ka ʻōnaehana limbic.Manaʻo ka poʻe noiʻi e hoʻāla ka waiʻona i ka uku o ka lolo a me ka ʻōnaehana hoʻopaʻi, e alakaʻi ana i ka hoʻokuʻu ʻana o ka dopamine, hiki ke ʻike ʻia i nā kānaka a me nā holoholona, a ua pale ʻia kēia kaʻina hana ma hope o ka mālama ʻia ʻana o nā ʻiole, hiki ke alakaʻi i ka uku liʻiliʻi o ka waiʻona. ka hoʻopaʻi ma ke kino, manaʻo ka poʻe noiʻi.
I ka hopena, hōʻike nā hopena o kēia noiʻi e hiki i ka somallutide ke hōʻemi i ka inu ʻawaʻawa, hiki ke hoʻopili ʻia e ka hōʻemi ʻana i ka ʻenehana hoʻopaʻi / hoʻopaʻi a me ka hana o ka nucleus accumbens."E like me ka hoʻemi ʻana o ka somallutide i ke kaumaha o ke kino i nā kāne ʻelua o nā ʻiole inu waiʻona, e nānā nā haʻawina lāʻau i ka wā e hiki mai ana i ka maikaʻi o ka somallutide i ka hōʻemi ʻana i ka inu ʻawaʻawa a me ke kaumaha o ke kino i nā poʻe maʻi keu me ka maʻi inu waiʻona."
Ka manawa hoʻouna: Nov-07-2023