hoʻolauna
ʻO Gorelatide, ka mea i kapa ʻia ʻo n-acetyl-serine - aspartic acid - proline - proline - (N-Acetyl-Ser-Asp-Lys-Pro), i hoʻopau ʻia ʻo Ac-SDKP, he tetrapeptide endogenous, nitrogen end acetylation, laha nui ʻia i loko. nā ʻiʻo like ʻole a me nā wai kino i loko o ke kino.Hoʻokuʻu ʻia kēia tetrapeptide e ka prolyl oligopeptidase (POP), ka mea i kumu nui ʻia e kāna thymosin precursor.ʻO ka manaʻo i loko o ke koko maʻamau ma ka pālākiō nanomole.
okinetics
Wahi a ka haʻawina pharmacokinetic o Gorelatide, ma hope o ka hoʻokele intravenous, hoʻohaʻahaʻa koke ʻo Gorelatide me ka hapalua o ke ola o 4 ~ 5 mau minuke.Hoʻomaʻemaʻe ʻia ʻo Gorelatide mai ka plasma kanaka e nā ʻano hana ʻelua:①Angiotensin-hoʻololi enzyme (ACE) - alakaʻi hydrolysis;②kānana glomerular.ʻO ka hydrolysis o ka angiotensin converting enzyme (ACE) ke ala nui o ka metabolism gorelatide.
Hana olaola
ʻO Gorelatide kahi ʻano multifunctional physiological regulatory factor me nā hana olaola like ʻole.Ua hōʻike mua ʻia e hiki iā Gorelatide ke pale i ke komo ʻana o nā pūnaewele hematopoietic kumu i loko o ka māhele S a hoʻopaʻa iā lākou i ka pae G0, ke kāohi nei i ka hana o nā pūnaeho hematopoietic stem.Ma hope mai ua ʻike ʻia hiki iā Gorelatide ke hoʻomaikaʻi i ka hiki ke kanu hou ʻana i ka epidermal ma o ka hoʻoikaika ʻana i ka hoʻokumu ʻana o nā kīʻaha koko a hoʻolalelale i ka hoʻōla ʻana i nā ʻeha i nā grafts epidermal vascularized i poino.Hiki i ka Gorelatide ke pale i ka hoʻokaʻawale ʻana o nā pūnaewele iwi o ka iwi i hoʻoulu ʻia e MGM i macrophages, no laila ke pāʻani nei i kahi hana anti-inflammatory.Ua ʻike koke ʻia ʻo Gorelatide e kāohi i ka hoʻonui ʻana o nā ʻano mea like ʻole.
hoʻohana
Ma ke ʻano he polypeptide organik, hiki ke hoʻohana ʻia ʻo Gorelatide ma ke ʻano he lāʻau lapaʻau.
Ka manawa hoʻouna: Apr-26-2023